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KMID : 0613820090190050680
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Journal of Life Science
2009 Volume.19 No. 5 p.680 ~ p.683
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Linoleic Acid from Bamboo (Phyllostachys Bambusoides) Displaying Potent α- Glucosidase Inhibition
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Jung Sun-In
Kang Su-Tae
Choi Cheol-Yong
Oh Kyeong-Yeol
Cho Jung-Keun
Park Ki-Hoon
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Abstract
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Glycosidase inhibitors are major targets in the treatment of type Ⅱ diabetes, cancer and viral infections. This study was carried out to investigate the glycosidase inhibitory substances from bamboo (Phyllostachys bambusoides). Bamboo was extracted with methanol and then further fractionated with n-hexane, chloroform, n-BuOH and aqueous to get an active fraction. All extracts were evaluated for α-glucosidase inhibitory activities to identify the n-hexane fraction with 33.5 ㎍/ml of IC50 value. Active compound 1 in the n-hexane fraction was identified as linoleic acid, which exhibited inhibitory activity with 12.4 ㎛ of IC50 value. Mechanistic analysis showed that linoleic acid exhibited noncompective inhibition. This is the first study in which bamboo is reported to show α-glucosidase inhibitory activity.
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KEYWORD
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Glycosidase, α-glucosidase inhibitor, Phyllostachys bambusoides, linoleic acid
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